|2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羟基-10,13-二甲基十六氢-1H-环戊二烯并[a]菲-17-基)戊酰胺基)乙磺酸钠盐水合物|CsnPharm

CAS No.: 345909-26-4

牛磺胆酸钠水合物 Catalog No. CSN13645

Synonyms: Sodium taurocholate hydrate;N-Choloyltaurine sodium salt hydrate;牛磺胆酸钠水合物

Taurocholic acid sodium is a deliquescent yellowish crystalline bile acid involved in the emulsification of fats.

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描述Taurocholic acid (TCA) sodium, a conjugation of cholic acid with taurine, is one of the main bile acids that is elevated in liver disease. In pretreated gingival fibroblasts and HSC-2 cells, TCA considerably reduced the expression of IL1β, IL6, and IL8. TCA has anti-inflammatory activity in gingival fibroblasts, human oral squamous cell carcinoma cells and macrophages in vitro^[2]. TCA increased the expression of α-SMA, type I collagen, and TLR4 in LX-2 cells (Hepatic stellate cells). TCA promoting liver cirrhosis is likely through activating hepatic stellate cells via upregulating TLR4 expression^[3]. An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric musoca in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dose-dependent^[4]. Long-term supplementation with small doses of TCA was demonstrated to improve glucose metabolism in a diabetic rat model and may be a potential target for diabetes control^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7995 mL
- 8.9977 mL
- 17.9953 mL
- 5 mM
- 0.3599 mL
- 1.7995 mL
- 3.5991 mL
- 10 mM
- 0.1800 mL
- 0.8998 mL
- 1.7995 mL

技术信息

CAS号

345909-26-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H46NNaO8S

运输

蓝冰

分子量

555.70

别名

Sodium taurocholate hydrate;N-Choloyltaurine sodium salt hydrate;牛磺胆酸钠水合物;牛磺胆酸钠

溶解度

DMSO	75.0 mg/mL (135.0 mM)

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